Mayo River Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Ready to book your vacation to Mayo River?
Mayo River Hotel Deals
The Lodge at Primland, Auberge Collection
2000 Busted Rock Rd Meadows Of Dan VA
CA $2,207
CA $2,550 total
Oct 11 - Oct 12
includes taxes & fees
9/10 Wonderful! (34 reviews)
"Expedia y la propiedad no aclararon los cargos y tuve que esperar casi 1 hora a que acreditaron el total del dinero que ya había pagado por adelantado. Reserven directamente"
Reviewed on Aug 28, 2026
Econo Lodge Martinsville
1755 Virginia Ave Martinsville VA
Fully refundable
CA $86
CA $96 total
Oct 24 - Oct 25
includes taxes & fees
6.6/10 (553 reviews)
"I believe that a reviewer described the neighborhood as “sketchy”. I’m not sure if I agree: it is, after all, it’s motel row. However, one could describe the motel as “sketchy “. The toilet looks like it came from a truck stop. The bathroom door hinges are rusty and who knows when the walls were ..."
Reviewed on Sep 30, 2026
Comfort Inn Martinsville
378 Commonwealth Blvd W Martinsville VA
Fully refundable
CA $148
CA $167 total
Oct 25 - Oct 26
includes taxes & fees
6.8/10 (702 reviews)
"No microwave, no fridge, room door was in bad shape and had to slam to close, no shelf/place in shower for soap or shampoo, hotel front door was broken. Not worth the money."
Reviewed on Oct 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Mayo River attractions
Reynolds Homestead
You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas.
Frequently asked questions
How much does a Mayo River vacation package cost?
Handcraft your Mayo River package from as low as . Choose from any combination of flights, hotels and rental cars to create the trip you've long been dreaming about. Be sure to add on one or two experiences!
How do I get a cheap travel package to Mayo River?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Hotels, flights, activities and rental cars — we've got everything you need. Choose the combination that best fits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties throughout the world, which lets you customize your Mayo River getaway.
Where should I stay in Mayo River?
A vacation in Mayo River wouldn't be complete without a visit to Reynolds Homestead. Why not stay within walking distance of this great attraction?
How far in advance should I book my Mayo River vacation?
Get rewarded with the biggest variety and the cheapest prices by booking your Mayo River vacation early. Airlines generally advertise flight tickets around a year prior to departure, so start locking things in as soon as you can. That being said, Expedia is committed to providing you with the best bargains around, so it's never a bad time to book your dream vacation!
What does an Expedia Mayo River travel package include?
Rental cars, flights and hotels — we have them well covered. With Expedia, you can shape your Mayo River travel package however you want. All you have to do is figure out just what you need. Once you've made your booking, you can add extras like tours and activities. The more you bundle, the more you save!
What should I know before booking a Mayo River travel package?
You can save a tidy sum by bundling your hotels, flights and rental cars. Once you've created your package, you can add on things like activities or tours. Your next awesome vacation is only a few clicks away.
Can I choose my airline with a Mayo River Expedia vacation package?
Most definitely. Expedia has over 550 airline partners to pick from worldwide. With so many choices, finding the ideal carrier to fly you to Mayo River will be a cinch.
If I'm not able to travel, can I cancel my Mayo River vacation package?
It is possible to cancel your Mayo River booking if your travel plans have changed. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal for more information.
Explore a world of travel with Expedia
- Fairfield Inn by Marriott Christiansburg
- Spa Hotels in Fancy Gap
- Hillsville Hotels
- 4 Star Hotels in Martinsville
- Motel 6 Hotels in Fancy Gap
- Red Roof Inn Hotels in Southwestern Virginia
- Pet-Friendly Hotels in Fancy Gap
- Cabin Rentals in Westlake Corner
- Motels in Henry
- Stellenbosch
- North Shore Hotels
- Quality Inn Dutch Inn
- Hampton Inn Christiansburg/Blacksburg
- Ridgeway Hotels
- Blackberry Hotels
- Blue Ridge Manor B&B
- Marriott Hotels & Resorts in Shawsville
- La Quinta Inn & Suites Hotels in Rocky Mount
- Hotels near Harvester Performance Center
- Quality Inn Radford
- Private 11
- Cabin Rentals in Elliston
- Soak in the hot tub @ Stonewood Manor - Where Luxury and Cozy Meet.
- Indulgent Log Cabin near Parkway
- Apartments in Willis
- Baymont by Wyndham Rocky Mount
- Country View Inn
- Comfort Inn & Suites Christiansburg I
- Quality Inn Christiansburg
- Best Western Hotels in Hillsville
- Hotels near Martinsville Speedway
- Pet-Friendly Hotels in Meadows Of Dan
- Homewood Suites By Hilton Christiansburg
- Hotels with Balconies in Southwestern Virginia
- Luxury Log Cabin with Copper Tub
- Martinsville Hotels
- Affordable Corporate Suites Christiansburg
- Lodges in Pine Creek
- Cabin Rentals in Hiwassee
- Callaway Hotels
- Blackwater Castle w/ Private Pool
- Pet-Friendly Hotels in Christiansburg
- B&B in Callaway
- Wingate by Wyndham Christiansburg
- Villas in Westlake Corner
- Cabin Rentals in Horse Pasture
- Blacksburg Hotels
- Quality Inn near Martinsville Speedway
- Best Western Hotels in Lambsburg
- Fancy Gap Hotels
- Mountain Lake Lodge
- Christiansburg Hotels
- Cabin Rentals in Peters Creek
- Radford Inn
- Roanoke Hotels
- Luxury Hotels in Pine Creek
- Downtown Floyd Retreat
- Econo Lodge Christiansburg
- Cabin Rentals in Riner
- Wytheville Hotels
- Super 8 by Wyndham Christiansburg
- Floyd Hotels
- Ridgeway INN
- Tru by Hilton Radford
- Laurel Fork Hotels
- Comfort Inn Blacksburg University Area
- Lambsburg Hotels
- Best Western Hotels in Southwestern Virginia
- Flights to Fancy Gap
- Flights to Roanoke
- Flights from Pilot
- Flights from Toronto (YYZ) to Roanoke (ROA)
- Flights from Lambsburg
- Flights from Montreal (YUL) to Roanoke (ROA)
- Flights to Christiansburg
- Flights from Copper Hill
- Flights to Shawsville
- Flights from Ararat
- Flights from Ferrum
- Flights to Pilot
- Flights from Hillsville
- Flights to Martinsville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
